The number is hard to assess correctly because weve been seeing a slight decline of tobacco use in the western countries (so called 1st world countries) but no reliable data can be obtained for the rest of the world namely, 3rd world and developing countries
I have seen zero bite issues even if you push it a bit
doi: 10.1097/MEG.0000000000001987 Sergio Cadoni, Sauid Ishaq, Cesare Hassan, Pemysl Falt, Lorenzo Fuccio, Keith Siau, Joseph W Leung, John Anderson, Kenneth F Binmoeller, Franco Radaelli, Matt D Rutter, Shinya Sugimoto, Humayun Muhammad, Pradeep Bhandari, Peter V Draganov, Piet de Groen, Andrew Y Wang, Andrew W Yen, Chris Hamerski, Henrik Thorlacius, Helmut Neumann, Francisco Ramirez, Chris J J Mulder, Eduardo Albniz, Arnaldo Amato, Makoto Arai, Adrian Bak, Maximilien Barret, Putut Bayupurnama, Ramsey Cheung, Hey-Long Ching, Hartley Cohen, Sunil Dolwani, Shai Friedland, Hideaki Harada, Yu-Hsi Hsieh, Bu Hayee, Toshio Kuwai, Vicente Lorenzo-Ziga, Mauro Liggi, Takeshi Mizukami, Donatella Mura, David Nylander, Snorri Olafsson, Silvia Paggi, Yanglin Pan, Adolfo Parra-Blanco, Rupert Ransford, Joaqun Rodriguez-Sanchez, Hakan Senturk, Noriko Suzuki, Chih-Wei Tseng, Hugo Uchima, Noriya Uedo, Felix W Leung

Mary Ward, president of the McLeod Addiction Center in Charlotte, North Carolina, has noticed the shift toward a preference for fentanyl in her home state
If you experience side effects like gum irritation, soreness, or nausea discontinue use