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Although many nicotiana are short-lived perennials, they're usually grown as annuals because they won't survive a hard frost

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Nicotine gum: Is clinically approved Contains no tobacco Is far safer than smoking Health experts worldwide agree that using nicotine gum is significantly less harmful than continuing to smoke or chew tobacco

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17 The quantification of nicotine and cotinine in performed in plasma, saliva, and urine of smokeless tobacco consumers