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However, in order for cigarette alternatives to contribute to public health in accordance with the concept of tobacco harm reduction, it is important not only to scientifically demonstrate that these products are less harmful than smoking but also that they are accepted by current adult smokers who would otherwise continue to smoke

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J Pharmacol Exp Ther 307(2):526534 Damaj MI, Grabus SD, Navarro HA, Vann RE, Warner JA, King LS, Wiley JL, Blough BE, Lukas RJ, Carroll FI (2010) Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice

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