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How Long Does Nicotine Stay in the System? Prism How Long Does Nicotine Stay in Your System? What happens after you stop smoking: A timeline Quitting smoking triggers a remarkable series of changes in the body, many of which begin within the first 72 hours. Before quitting, smokers experience several harmful effects due to nicotine and other Today is World No Tobacco Day. Smoking is the top cause of illness and death that can be prevented in Canada. Each year, close to 6,000 people in B.C. die from

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