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E-cigarettes have long been controversial

13 Based on a smaller number of studies, varenicline appears to be more effective than NRT or bupropion sustained-release

However, research shows that many smokers are dependent on the beneficial effects of nicotine to combat symptoms of underlying conditions [10] and that long-term nicotine abstinence may result in long-term discomfort for many smokers [94]

Cannabis and Cannabinoid Research However, regular use comes with a significant caveat: tolerance builds, the sleep-onset benefits fade over time, and withdrawal symptoms such as insomnia and vivid dreams can ultimately disrupt sleep worse than before cannabis was ever introduced