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Most tobacco products, including e cigarettes, contain nicotine, a chemical that can harm the heart, brain and whole body. As with other addictive products, using a nicotine product builds tolerance, leading to more Impact of Smokeless Tobacco Products on Cardiovascular Disease: Implications for Policy, Prevention, and Treatment Circulation Association of Smokeless Tobacco Use With Incident Peripheral Artery Disease: Results From the Atherosclerotic Risk in Communities Study American Journal of Preventive Medicine Ditching cigarettes for smokeless tobacco can help cut cardiovascular risks, study finds UCLA Revealing the Truth About Chewing Tobacco
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