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There isnt any harshness due to the lack of chemicals

Since then, just about every municipality followed, from New York City in 2003 to Chicago in 2006 to the entire state of North Dakota in 2012

They further conducted physiological testing on their participants, including pulse oximetry, gas tension, pulmonary function tests and blood analyses [65]

Massachusetts and California enacted the nations first statewide flavored nicotine bans in 2019 and 2020, although both contain exemptions

Tobacco substances undergo first-pass metabolism in the liver, exposing the organ to a complex array of over 4000 toxic chemicals, including nicotine, nitrosamines, aromatic hydrocarbons, and various carcinogens [2,3,4]