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The South Dakota Medicine journal writes of twin and family studies that have shown that there are several genes that cause an individual to become more susceptible to being addicted to nicotine. The genes in question determine how many receptors the brain produces to metabolize the nicotine in an inhalation

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We even see a specific mutational signature in other tissuessuch as the mouth, esophagus and lungsthat are directly exposed to tobacco carcinogens, said study senior author Ludmil Alexandrov, professor of bioengineering and cellular and molecular medicine at UC San Diego