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Due to the limited number of available datasets, no restrictions were applied regarding participant characteristics, publication year, or intervention type, as the small and methodologically diverse sample of studies made such distinctions impractical

The main limitation is reduced metabolism of endogenous AhR ligands often observed in various human cancers, which frequently leads to downregulation of CYP1A1 ( Circadian regulation Diurnal rhythmicity is observed in mice with coumarin hepatotoxicity, with more severe toxicity at ZT2 versus ZT14 (ZT, zeitgeber time

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