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This reward flood creates a euphoric "high," but the brain quickly adapts by reducing receptor sensitivity, causing tolerance

Vitolo said nicotine products are "so addictive that it would be unfair to take them away from long-time users." "And, because they are so addictive, it would be unfair to allow those currently too young to lawfully purchase these products to ever do so," Vitolo said

Interestingly, data from an in vitro BBB model showed that donepezil and memantine significantly reduced nicotine uptake (Nakanishi et al., 2018)

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