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To reduce the effect of bias, we adjusted observations that did not account for more than five confounders, including age and sex, because they were the significant bias covariates identified by the bias covariate selection algorithm 29 (Supplementary Table 7)

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and a lack of effective interventions, particularly those involving contact with healthcare professionals [5]

It saves lives and it saves the state money. Three tax increases on cigarettes since 1998 have brought the states revenue from cigarette taxes to nearly $400 million per year and have coincided with a 32 percent drop in adult smoking rates