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Importantly, although individual mutations and their associated GOF effects can result in variable therapeutic vulnerabilities, the restoration of WT p53 function exerts comparable effects across tumours with different mutant p53 in lung cancer mouse models that can be switched from mutant p53 to WT p53 [217]

These machines not only sped up production but also popularized pre-packaged rolling papers, making them widely accessible to consumers

This decreased circulation deprives skin cells of essential oxygen and nutrients, leading to accelerated aging, dull complexion, and impaired healing

She was never without dark glasses, she was always well-groomed, there was a consequential good-taste in the plainness of her clothes, the blues and greys and lack of luster that made her, herself, shine so

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