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[53] Epidemiologic studies have found that fecal bile acid concentrations are increased in populations with a high incidence of colon cancer

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It is well known that inhaled corticosteroids (ICSs) also increase the risk of pneumonia in people with COPD, and the increased risk of pneumonia in people treated with antipsychotics reinforces the need to use ICSs in line with the Global initiative for chronic Obstructive Lung Disease (GOLD) recommendations (i.e., based on previous exacerbation history and blood eosinophil count) as this will maximize the benefits of exacerbation reduction and consequent risk of respiratory failure, while minimizing the risk of pneumonia

Wen: Risk reduction depends on individual circumstances