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It is important to note that a filter must be HEPA-certified (it is not enough to claim that a filter is HEPA which many brands, including Levoit, do)

Tobacco smoke contains nicotine and other chemicals, such as cadmium, that can affect central nervous system structures [69] or stimulate expression of pro-inflammatory molecules resulting in peripheral and central sensitization which can contribute to the development of headache pain [70,71,72]

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Given the extent of regulatory interventions and controls already in place, there is evidently a shrinking menu of more conventional options left, with gains increasingly marginal