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PMC 7104367

59 In an earlier meta-analysis of smoking prevention programs, the researchers concluded that peer or social type programs should be continued as part of smoking prevention efforts, but that the overall magnitude of effect can be limited

26 Heng and colleagues 40 found a complete indoor/outdoor smoke-free policy in a womens federal prison eliminated differences in complications following dental extractions between smokers and nonsmokers

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Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers