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29 Xie et al suggested that long-term tobacco smoke exposure enhancing self-renewal ability, increasing the expression of CSCs markers and tumorigenic ability of human bronchial epithelial cells, the IL-6/Np63/Notch axis and Wnt/-catenin pathway play an important role in this process

Inflammation and Oxidative Stress Some aerosol compounds and flavoring byproducts can irritate tissues and may promote oxidative stress

In Alberta, the University of Calgary conducted a five-year study beginning in 2015 (73)