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This can be caused by an underlying medical issue (like heart or lung problems or an infection), or may occur in healthy people due to strenuous exercise, obesity, extreme heat or cold, or high altitudes

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The way that we conceptualise this is that if survival is long, and/or the treatment offers very large benefits, then the time spent pursuing treatment, you know, waiting in the chemotherapy unit, going for a CT scan, going to the emergency room because of vomiting after treatment, that time proportionately might be quite small, and for most patients it might be an easy trade-off decision Norman Swan : In other words, you're willing to invest in it for the upside