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Importantly, there was no evidence of a one-to-one substitution from using flavored tobacco products to non-flavored tobacco products because the total tobacco sales also decreased by 25% over the same period in San Francisco

The central nicotinic cholinergic receptors, namely the low affinity 7 and the high affinity 42 nicotinic receptors located in the ventral tegmental area (VTA), are stimulated by nicotine resulting in a rapid release of dopamine in the nucleus accumbens, mediating the rewarding and reinforcing effects of nicotine (Figure 1)

A biologist's view

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In 1993, New York Times columnist Robert Herbert wrote a piece criticizing civil rights organizations that took money from cigarette manufacturers, headlined Tobacco Hush Money for Black Leaders