cuban seed tobacco National Brand Rothschild 5" * 50 the Blackish Paw and the Tobacco Mosaic Virus and moderately resistant to the Environmental Necrosis. Cuban Seed | Cigar Aficionado

American Tobacco: Four Seasons Fine Tobacco American Tobacco boasts that they have created one of the true American Tobacco flavors

Nicotine from tobacco a "natural" pesticide

The similarities with TF Tobacco Vanille are very close to zero

Given that Balabanova and others found evidence of ingestion, this probably isnt a likely source unless there is some mechanism that cotinine can metabolize from the nicotine in insecticide applications or second-hand smoke

Both linkage studies and genome wide association studies (GWAS) have identified candidate genes/genomic regions associated with nicotine dependence ( Genetic factors significantly influence both smoking initiation and persistence, a schematic of these influences are presented in Figure 1, these include genes associated with differences in nicotine's metabolic capacity and nicotine effects on central nervous system neurotransmitter functionality, specifically the dose that modulate direct and indirect effects on nAChR, dopaminergic and opioidergic activity, respectively