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Although there is no proof which peoples were the first, many things suggest that Indians have been the first to discover and use the plant for various purposes including: smoking, medicine, religious, ceremonial purposes, as well as for trading (as money)

Moreover, several studies on nicotine pouches have been funded by the tobacco industry, leading to doubts about the reliability of these studies [54, 55]

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Because tobacco is certainly more dangerous than marijuana and may increase the potency and health hazards of marijuana when taken together, the researchers believe their results highlight the need to focus more narrowly on discouraging methods of marijuana use that incorporate tobacco rather than marijuana use itself

98(suppl.1):i3755