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Although several carcinogens were already known at the time (for example, benzo[a]pyrene was isolated from coal tar and demonstrated to be a potent carcinogen in 1933), none were known to be contained in adequate quantities in tobacco smoke

That means premium, niche, or older variants may not always be available

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6 The quality of the evidence regarding oncogenic effects is poor

The bottom is finished in a solid field of glossy black enamel, while the interior is clean and engine-turned, fitted with the original spring-loaded arm stamped Marathon Product. The case opens and closes smoothly and remains in excellent vintage condition, showing only light wear to the enamel and a small area of texture near the cartouche