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To offset these costs, the Regulations would need to reduce the annual rate of vaping product initiation by 1.03% relative to the baseline initiation rate

Replace every 12 months

DOI: 10.1111/j.1360-0443.2011.03770.x (accessed 20 August 2015)

For total cardiovascular disease, coronary heart disease, and stroke, similar patterns were seen in all three cohorts individually (supplemental tables 3-5)