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These effects are believed to be related to vasoactive and mast cell signaling pathways rather than impurity

The peptide complex restores extracellular matrix homeostasis by increasing the synthesis and turnover of collagen, elastin, and glycosaminoglycans, as well as by modulating the balance between metalloproteinases (MMPs) and their inhibitors (TIMPs), thus supporting both matrix remodeling and scar resolution 2,3

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These pathways create a feed-forward cycle where altered lipid metabolism amplifies cellular stress and inflammation (79, 80)

(34697528, 35521821) Various options to avoid this issue: Intravenous fosphenytoin avoids the issue entirely