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Moreover, a Korean retrospective multicenter cohort study that enrolled 728 CD patients demonstrated that stricturing, penetrating disease behavior, and smoking habits at the time of diagnosis are independent predictors of CD-related surgery 23

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Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE

Volkow ND, Wang GJ, Newcorn J, Telang F, Solanto MV, Fowler JS et al (2007)