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111-31), we intended FDAs premarket review of new tobacco products to be utilized as an important tool to prevent new products from entering the market that are likely to increase youth use of tobacco

However, the report also found conclusive evidence that completely substituting e-cigarettes for combustible tobacco cigarettes reduces users exposure to numerous toxicants and carcinogens present in combustible tobacco cigarettes. In terms of nicotine intake, the report uncovers substantial evidence that nicotine exposure from e-cigarettes among experienced adult e-cigarette users can be comparable to that from combustible tobacco cigarettes. There is also substantial evidence that heart rate increases after nicotine intake from e-cigarettes, and that some chemicals present in e-cigarette aerosols (e.g., formaldehyde, acrolein) are capable of causing DNA damage and mutagenesis. This is important because we can plausibly infer from this that long-term use of e-cigarettes could raise the risk of cancer, write the authors of the report

Still subject to full provincial tobacco tax

It emphasie the need for better coordination among healthcare providers to improve patient care and information access

doi: 10.1016/j.pharmthera.2019.05.001