One is that it alters ABC transporters proteins that move drugs and other toxic substances out of cells
Symptoms of Overdose A large overdose causes: Drowsiness Intoxication Rapid onset of sleepiness Fluctuating consciousness (periodically waking/sleeping is a relatively typical phenomenon) Absence periods Nausea Vomiting Tremors Dizziness Muscle cramps Ataxia Choreoathetosis Brief unconsciousness Slow pulse Motor agitation Affect lability, aggression Rapid onset of sleepiness Fluctuating consciousness Unconsciousness, coma Small pupils, ophthalmoplegia (strabismus) Hypotension Bradycardia ECG changes, possible AV block I-III or high QRS amplitudes Irregular pulse Slow and irregular breathing, respiratory depression Generalized seizures Vomiting Risk of aspiration of stomach contents into the lungs Hypothermia ACUTE MANAGEMENT The treatment of acute overdose is primarily symptomatic, and no antidote exists

Researchers took measurements of salivary cotinine levels at baseline and towards the end of pregnancy, and gathered information about each participants use of cigarettes or types of NRT, respiratory symptoms, and the birth weight and other data of their babies at birth
Philip Morris International (PMI) reportedly purchased a patent for a genetically modified cannabis plant in 2018
5 Tips to Quit Smoking for Fertility Smoking can cause health problems and even fertility issues