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On the other hand, the ingredients used in the tobacco-free herbal products are said not to contain nicotine, but reviews of the research emphasize the point that the absence of the substance does not exclude risks of exposure , the combustion process generating particles such as "particulates." Accordingly, these latter categories tend to be treated individually, one based on stimulant dependency potential, the other on the combustion process for exposure

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The normal vascular endothelium regulates vasodilation and vasocontraction, proliferation and antiproliferation of vascular smooth muscle cells, coagulation and anticoagulation, inflammation and anti-inflammation, and oxidation and antioxidant effects, which work in balance to regulate and maintain vascular tone and structure [53]