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(The National Academies Press) Negrini S, Gorgoulis VG, Halazonetis TD

Six other studies that examined similar comparisons (sample size 80837) reported on smoking cessation and reduction but were all of very low certainty.29 35 One RCT that compared nicotine e-cigarettes to NRT ( n = 135) suggested there may be a large effect of e-cigarettes on cessation (161 more per 1000, 95% CI 15 more to 785 more

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