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It was reported that the upregulation of miR-21-3p or miR-27b-3p in CSE-treated Beas-2B-derived exosomes could not only induce macrophages RAW264.7 to express CD86, CD80, CD163 and CD206, but also promote them to produce TNF-, IL-6, inducible nitric oxide synthase (iNOS), IL-10, Arginase (Arg)-1 and transforming growth factor-beta (TGF-), suggesting their ability to polarize the macrophages into M1 phenotype and M2 phenotype simultaneously [83]