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(Wu et al., 2019) demonstrated in human umbilical vein ECs and arteries of HHcy mice that Hcy triggers the expression of ER oxidoreductin-1 (Ero1), leading to ER stress and subsequent inflammation

However, B12 bound to TC forms a complex known as holoTC, which is the biologically active form of B12, that is taken up into cells via endocytosis using a specific CD320 receptor (Quadros, 2010)