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This organization and synthesis demonstrates that each of the four steps in risk assessment and in risk management are informed by: the four specific questions posed by the committee (described above) as a means to answer its charge in order to provide regulatory, scientific, and medical guidance, the evidence reviewed by the committee in each of the disease- specific chapters (contained in Section II and summarized in Chapter 5), the principal conclusions of the committee (found in Chapter 8) related to the questions contained within the charge, specific recommendations of the committee related to a comprehensive surveillance system (Chapter 6) and regulatory principles (Chapter 7), and the research gaps identified (Chapter 5 and Section II)