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Iconoclastic director David Lynch, who with his darkly surreal films brought the avant-garde shrieking and scratching into the mainstream, has died at the age of seventy-eight

While nicotine can temporarily enhance alertness and attention, chronic smoking is associated with: Reduced memory performance Slower processing speed Increased brain aging Higher risk of dementia Long-term smoking restricts blood flow to the brain and increases oxidative stress, leading to structural and functional brain changes

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Regulatory and ethical pressures pose the greatest unquantifiable threats