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In phase 3 clinical trials, participants using semaglutide (2.4 mg once weekly) showed 10-15% body weight reduction on average after 68 weeks

J Cyst Fibros 2:195198

Without human trials, clinicians cannot reliably determine appropriate dosing, long-term risks or whether benefits outweigh risks

10.1016/j.molcel.2006.12.009 Mol

Therefore, increased lipid utilization in the mitochondria of skeletal muscle cells is associated with continued muscle contraction, and the number and activity of mitochondria influence the utilization of fatty acids in muscle cells