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carried out a clinical study in a total of 223 overweight/people with obesity (125 females and 98 males)

doi: 10.1007/s00259-019-04543-w 73 MilanGReemaGSimoneKKevinDSJamesJHIngoKMet al

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However, as detailed above, cells that exhibit higher levels of mitochondrial activity are less sensitive to 5FU treatment, and those with compromised mitochondrial function are more sensitive, correlating with intrinsic resistance