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This work has been extended to the determination of a number of enzyme complex crystal structures which show that very large ligands are readily accommodated into this substrate binding site and in all, but one case, causes no significant movement of protein side-chains

If you're wondering why you might have low homocysteine, here are common culprits: 1

Br J Cancer 2001

CD8+HLA-DR+ t lymphocytes are increased in common variable immunodeficiency patients with impaired memory b-cell differentiation

Moreover, at low doses, HNE exerts an anti-cancer effect, by inhibiting cell proliferation, angiogenesis, cell adhesion and by inducing differentiation and/or apoptosis in various tumor cell lines