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Only slight reversible creatinine decreases at very high doses (2 mg/kg) were noted

Hypermethylation of the transporter 1 ATP-binding cassette subfamily B member (TAP1) has been shown to suppress TAP1 expression in immunoreactive cancer stem cells (CSCs) within murine models of breast carcinoma, these CSCs manifest a downregulation in the expression of transporter associated with antigen processing genes and co-stimulatory molecules, thereby reducing their sensitivity to T-cell-mediated immune surveillance and potentially culminating in immunotherapy resistance

Proc Natl Acad Sci USA 101:59645969

10.1038/ncb3350 142 ThapaA.WebsterT

For laboratory preparation, researchers typically reconstitute with bacteriostatic water, added slowly down the inside wall of the vial and swirled gently rather than shaken