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In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]

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In addition to establishing a ferroptosis-related prediction model using a TCGA dataset, the performance of the model was verified using GEO datasets, which markedly increased the reliability of the findings