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Jitteriness, anxiety, or heart palpitations are not normal and suggest either excessive caffeine intake combined with the B12 surge, histamine sensitivity producing an adrenaline-like response, or an underlying thyroid or adrenal condition amplified by the metabolic boost

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Interestingly, the gut metabolic module aspartate degradation I, which converts L-aspartate to oxaloacetate by aspartate aminotransferase, was elevated in SAD patients and the authors hypothesized that bacterial aspartate aminotransferase enzyme activity may represent a link between gut microbiome function and the tryptophan-kynurenine pathway, a key physiological system in psychiatric disorders (Butler et al., 2023)

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Polystyrene petri plates (100 mm x 15 mm) with 20 mL of LB agar and appropriate antibiotics as needed were spread with 300 l of bacterial suspension

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