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As a central energy sensor, AMPK extends lifespan by promoting autophagy via mTOR inhibition and ULK1 activation, enhancing mitochondrial function through PGC-1/SIRT1 signaling and improving the NAD + /NADH balance, suppressing inflammatory responses via NF-B inhibition, and modulating stress resistance via the FOXO3/p53 pathways, thereby linking metabolic regulation to aging suppression 41

KDS12025 significantly improved memory impairment and reversed astrogliosis in the Sc-shRNA group, but these effects disappeared in the Hb-shRNA group (Fig

Cytotoxic payloads: from classical toxins to targeted agents Cytotoxic payloads are the core components of ADCs responsible for direct tumor cell killing [90]

The final section of the chapter presents the most recent findings related to the occurrence of flavonol aglycones and flavonol glycosides in various plant sources and food products, their separation, identification, and quantification by modern techniques, optimized production of flavonols using biotechnology, as well as obtaining flavonol-based formulations for food applications

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