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NNMT expression in white adipose tissue has been a particular focus of published pre-clinical work

Multiple studies have demonstrated MOTScs ability to enhance lipid beta-oxidation, increase thermogenic brown fat, decrease fat gain on a high-fat diet, and improve glucose uptake during glycolysis

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Animals treated with 5-amino-1MQ showed no signs of toxicity, behavioral changes, or adverse effects at therapeutically effective doses

Some studies have suggested that GH and IGF-1 can increase muscle mass and reduce body fat, but its mostly been shown in animals and people with low levels of GH, like the elderly or those with a medical issue causing a deficiency