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Some researchers have shown that metformin activates AMPK and triggers the downstream GSH system to slow DOX-mediated oxidative impairment in the myocardium [225, 226]

Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo

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Studies are revealing that in some cases checkpoint inhibitor MAb alone may induce clinical benefit, while in other cases, additional immune-mediating agents are necessary [140]