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Series B, Biological Sciences

Limitationa and perspectives Targeting ferroptosis appears to have a favorable impact on the clinical treatment of multiple human diseases

The loss of BRCA1 and BRCA2 leads to the impairment of homologous recombination repair functions, rendering tumor cells unable to effectively repair DNA damage, consequently causing genomic instability and tumor progression ( When these cells experience DNA damage, they cannot repair it through the HRR pathway, leading to cell death (49)

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Pioglitazone, a diabetes medication, may benefit selected patients with biopsy-proven NASH, but is also specialist-led and off-label , with potential risks including weight gain, fluid retention, heart failure, and increased fracture risk