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17,18 The introduction of Oct4, Sox2, and Klf4 (OSK) restores the DNA methylation pattern and transcriptomes of young mice, promotes axonal regeneration after injury, and reverses visual loss in glaucoma mice and aged mice

Understanding and addressing irAEs is a pressing issue for another reason as well: given that only about a third of cancer patients respond to immune checkpoint inhibitors, research labs and pharmaceutical companies are doubling down on efforts to expand the efficacy to more patients, and one of the approaches is to combine different immunotherapeutics to target different pathways

You should not expect that such favorable returns can be consistently achieved