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The organization takes place in the lumen (inner space) of the thyroid follicle

Activation of the nuclear factor erythroid-2 related factor-2 (Nrf2) pathway involves the transcription of multiple (antioxidant) proteins, including heme oxygenase 1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO-1), which protect cells from ROS- and cytokine-induced damage and cell death