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As BMAL1 is the direct regulator of Nrf2, its deletion down-regulates the Nrf2 mediated antioxidant pathways, and there will be a significant increase in the production of IL-1 (Wible et al., 2018)

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doi: 10.1016/j.celrep.2018.02.060 [DOI] [PMC free article] [PubMed] [Google Scholar] 197

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