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[DOI] [PubMed] [Google Scholar] 73.Le Borgne F., Ravaut G., Bernard A., Demarquoy J

The calcium overload activates calcium-dependent enzymes (e.g., calpain, nitric oxide synthase [NOS]), generating ROS and mitochondrial dysfunction, which triggers the release of apoptosis-inducing factor and cytochrome C, thereby activating caspase-9 and caspase-3