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Paternal mitochondrial inheritance and epigenetic remodeling in the zygote Following the establishment of maternal developmental competence in the oocyte, fertilization initiates coordinated remodeling of paternal mitochondrial components and the zygotic epigenetic landscape

YAP and YY1 are both activated by shear stress and are associated with increased endothelial proliferation, leading to higher permeability and promoting plaque formation

While these findings highlight multiple possible mechanisms, the pathways remain under active exploration