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The most common side effects of oral silymarin ingestion include:2 Abdominal pain/fullness Bloating Bowel changes Diarrhea Dyspepsia (indigestion) Flatulence Headache Nausea Pruritus (itching) Of note, there's at least one case report of more severe instances of the above, along with sweating, colicky pain, weakness, and collapse, in a 57-year-old woman after taking a milk thistle capsule

Typical Research Dosages Dosage: 250 mcg to 500 mcg, administered twice daily

2024;96:e29887

Urun C, Chopo-Escuin G, Tommassen J, Mainar-Jaime RC, Arenas J

Adv Healthcare Mater, 2022, 11: 2101926 Acknowledgements This work was supported by the National Natural Science Foundation of China (62175262), the Science and Technology Innovation Program of Hunan Province (2022RC1201), the Fundamental Research Fund for the Central South Universities (2020CX021), the Key R & D plan of Hunan Province (2022SK2101), and the Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University