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Mutations in AR receptor, AR overexpression, intracrine production, contorted expression of enzymes and cofactors of AR, autonomous activation of AR signaling by cytokines in the absence of androgen ligands, and the presence of multiple splice variants of AR are the main causative agents responsible for the therapeutic failure [12, 13]

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Harris JP, Burrell JC, Struzyna LA, et al

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Environ Pollut 287:11759710

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2023 Feb 19 Anitua, E., Prado, R., Snchez, M

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