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Moco is synthesized de novo by a multistep metabolic pathway involving four genes: MOCS1 , MOCS2 , MOCS3 , and GPHN (see Figure 1 )

Tian et al., 2022) have confirmed that Bifidobacteria can be used to treat depressive symptoms, but the underlying mechanisms have not been completely elucidated, which may be related to reducing the abundance of pathogenic bacteria, exerting the anti-inflammatory effects, improving the permeability of intestinal barrier, regulating the tryptophan levels, affecting 5-hydroxytryptamine (5-HT) synthesis, and regulating hypothalamus-pituitaryadrenal (HPA) axis (Figure 1)

Moreover, 1000 g/mL GE completely reverses A-induced cytotoxicity ( There is also evidence indicating that Gastrodin can improve memory in mice, reduce the deposition of A amyloid plaques, the number of astrocytes and activated microglial cells, and decrease the expression of TNF- and IL-1 in N9 cells

Another point of interest regarding B12 supplementation is the commonly held belief that intramuscularinjections of B12 are more effective than oral supplementation

Fox Foundation (Therapeutic Pipeline Program #9998 (Cullen)), the Department of Veterans Affairs (BLR&D Merit Review I01-BX003748 (Cullen)), the National Institutes of Health (BRAIN Initiative U01-NS094340 (Cullen) & T32-NS043126 (Harris)), and the National Science Foundation Graduate Research Fellowship (DGE-1321851 (Struzyna))